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High-Pressure Homogenizer

Model: Bionoon--05HL
Item NO.: BN52008

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+86 18621179858 , +86 15000983478

echo@bionoon3.com

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PRODUCT DETAILS

Application Industry	Application Project
Biological Engineering	Vaccines (human meningococcal vaccines, conjugate polysaccharide vaccines/veterinary VERO cells, insect cells, 293 cells), protein therapeutics (E. coli, yeast cells: norovirus, HPV vaccines), diagnostic reagent raw materials (IVD), enzyme engineering, etc.
Pharmaceutical preparations	Fat emulsions, liposomes, lipid nanoparticles, suspensions, etc.
Food Emulsification	Juice, milk, functional beverages, food additives, flavorings, etc.
Cosmetics	Liposome cosmetics, creams, lotions, sodium hyaluronate, coenzyme Q10, etc.
Fine Chemicals	Nano-cellulose, polymer materials, ink, nano-fuel, materials, etc.

I. Principle Overview

The high-pressure homogenizer employs a reciprocating plunger pump to draw samples through a single-phase valve into the high-pressure pump head. The sample is then forced into a narrow gap (the homogenizing valve). As particles pass through this valve, they undergo extreme compression at pressures as high as 1000 bar. Upon exiting the valve, the particles return to atmospheric pressure. This instantaneous pressure release achieves uniform and fine particle refinement. Generally, a greater pressure differential yields superior homogenization. During this process, the extreme velocity and unique trajectory generate explosive forces alongside immense shear and impact forces, collectively achieving excellent homogenization of the sample.

In summary, the homogenizing effect of the homogenizer primarily stems from three internal mechanisms: cavitation effect, shear effect, and impact effect.

II. Product Features

1. Product Applications: Cell disruption, flavorings, milk, health supplements, microspheres, and related fields.

2. Minimum Processing Volume: 60ml, feed particle size less than 500μm.

3. Drive System: ABB electric single-plunger motor delivers high refinement precision with crankshaft-connecting rod design for enhanced equipment stability.

4. Design Pressure: 1200 bar.

5. Operating Pressure: 1000 bar, adjustable to user-specified requirements.

6. Flow Rate: Variable frequency control system, 40-60 liters per hour.

7. Temperature Control: Standard online temperature control module (built-in module directly absorbs heat generation to preserve material activity), with adjustable temperature settings.

8. Pressure Detection: High-precision sensor, pressure range 0~2000 bar, accuracy 1 bar.

9. Main Motor: 5.5kW, 6-pole high-power motor at the drive end, ensuring stable operation under high pressure.

10. Voltage and Frequency: 380V, 50Hz.

11. Homogenizing Valve: Single-stage homogenizing valve with diamond material for exceptional durability.

12. Safety Control: Automatic circuit breaker protection in the control panel.

13. High-Pressure Plunger Material: High-precision zirconia ceramic with excellent wear resistance.

14. Equipment Components: Compliant with GMP and FDA sanitary standards. Plungers made of zirconia ceramic; all material piping constructed from 316L stainless steel and 2205 duplex stainless steel.

15. Equipment Material: Constructed from acid-resistant, alkali-resistant, high-temperature resistant, wear-resistant, tensile-resistant, and corrosion-resistant 316L stainless steel. Core components utilize special ceramics for exceptional durability and extended service life.

16. Triple Overpressure Safety Protection System:

(1) Equipped with Bosch frequency converter for overload start protection.

(2) Utilizes high-precision pressure sensors; when pressure exceeds 10% of sensor range, the sensor transmits a signal to the unit, triggering automatic machine shutdown.

(3) Features a cooling module safety valve for pressure relief protection.

III.Core Component Description

High-Pressure Module: SAF2507 High-Density Forged Bidirectional Special Stainless Steel

Plunger: Zirconia Ceramic, Surface Polished to 0.2μm

Homogenizer Valve Body: SAF 2205 Duplex Stainless Steel

Homogenizer Valve Assembly: Stellite Alloy Material

Feed Valve Seat: Stellite Alloy

Pressure Display: High-precision pressure sensor 0~2000 bar

Plunger Seal: High-density composite plunger seal

Safety Device: Overpressure and overcurrent alarm with automatic shutdown, entering standby mode

Power System:

Bearings: Sweden SKF Bearing System